Canine Distemper- Adenovirus Type 2, Parainfluenza-Parvovirus Vaccine. Modified Live Virus. For the vaccination of healthy dogs as an aid in the prevention on disease caused by canine distemper virus, adenovirus type 1 (hepatitis), adenovirus type 2 (respiratory disease), canine parainfluenza virus, and canine parvovirus. Inject 1 dose subcutaneously or intramuscularly. The initial dose may be given at 6 weeks of age or older. Repeat at 2-4 week intervals until the dog is 12 weeks of age. A minimum of 2 doses is required for primary immunization. Annual revaccination with one dose is recommended. Do not vaccinate pregnant bitches.