Canine Distemper- Adenovirus Type 2- Measles- Parainfluenza Vaccine. Modified Live Virus. For vaccination of healthy dogs 6-12 weeks of age as an aid in preventing disease caused by canine distemper virus, canine adenovirus type 1, canine adenovirus type 2, and canine parainfluenza virus. Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided. Shake well and administer 1 mL intramuscularly. Administer a single 1 mL dose to healthy dogs between 6 and 12 weeks of age. Dogs should be revaccinated at 14-16 weeks of age with a canine distemper-adenovirus type 2, and canine parainfluenza vaccine. Annual revaccination is recommended. Vaccination of pregnant bitches should be avoided.